Nicorandil inhibits osteoclast differentiation in vitro
نویسندگان
چکیده
منابع مشابه
Indoxyl sulphate inhibits osteoclast differentiation and function.
BACKGROUND Patients with chronic kidney disease (CKD) develop various bone abnormalities characterized by impaired bone remodelling. Recent data suggest that accumulation of the uraemic toxin indoxyl sulphate (IS) may be one of the factors involved in bone abnormalities in CKD patients. Indeed, it was recently reported that IS induces skeletal resistance to parathyroid hormone in cultured osteo...
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INTRODUCTION Adult bone is continuously remodeled through the formation of new bone tissue by osteoblasts and the resorption of old bone tissue by osteoclasts [1]. In general, an imbalance in bone remodeling that is caused by increased bone resorption over bone formation leads to most adult skeletal diseases including osteoporosis and rheumatoid arthritis [2]. Therefore, the enhanced activation...
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The adipokine nicotinamide phosphoribosyltransferase (Nampt), also known as pre-B-cell colony-enhancing factor or the insulin-mimetic hormone visfatin, has a crucial role in the conversion of nicotinamide to nicotinamide mononucleotide during biosynthesis of the coenzyme nicotinamide adenine dinucleotide. Previous reports have demonstrated the inhibitory effects of Nampt on osteoclast formation...
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Osteoclasts, the cells capable of resorbing bone, are derived from hemopoietic precursor cells of monocyte-macrophage lineage. The same precursor cells can also give rise to macrophages and dendritic cells, which are essential for proper immune responses to various pathogens. Immune responses to microbial pathogens are often triggered because various microbial components induce the maturation a...
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Background The structure and function of bone tissue is maintained through a constant remodeling process, which is maintained by the balance between osteoblasts and osteoclasts. The failure of bone remodeling can lead to pathological conditions of bone structure and function. Remifentanil is currently used as a narcotic analgesic agent in general anesthesia and sedation. However, the effect of ...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2016
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2016.10.034